Qt Quick allows you to create web-like UI on desktop. However, since VTK can now run in the web browser and you can run your C++ code (using webassembly) and Python code (for example using pyodide) natively in the web browser, too, you might consider cutting out Qt and use a web GUI framework instead (such as React or Angular).
Using Javascript framework instead of Qt for the GUI widgets may be very significant effort and most C++/Python on the web technologies are not mature yet, but the Qt company does not behave nicely (they make life of free Qt users increasingly more difficult; and licensing terms and costs for commercial Qt are unreasonable) and more and more users demand running their software natively in the browser. Therefore, web GUI should be seriously considered, especially for new projects and that can afford to use an evolving technology stack in the next few years.
have an idea—why don’t we try creating a launcher? We could first use C++ to create a Qt application and register QQuickVTKRenderItem with Qt in advance. With this, the launcher would be completed, and then we could expose this launcher to Python-Embedding, allowing the launcher to execute commands from Python. Wouldn’t this also allow PyQt or PySide6 to run a QtQuick interface while achieving compatibility with VTK? My C++ coding skills are very limited, but I think this could be feasible. Perhaps this GitHub project might offer more inspiration: GitHub - skywind3000/PyStand: 🚀 Python Standalone Deploy Environment !!.
3D Slicer, MeVisLab, maybe even MITK all use PythonQt to embed Python in a VTK/Qt application. Everything works very nicely. The drawback of PythonQt that the application is C++ first, and Python is embedded. Some Python developers don’t like this. Also, PythonQt is not as popular as PyQt and PySide.