So I have quickly re-educated myself on the topic of whole slide images and how these scanning companies store the images. It looks like the file format stores the image levels for an image pyramid already. The Domains/Microscopy module which utilizes openslide to read these formats by default reads in the base level. However, in openslide you can set which level (hence the resolution) you would like to read the image in. This choice is presently not available in the vtkOpenSlideReader macro so one may be better off incorporating openslide. This would save time as we wouldn’t have to resize the image at all.